Rasmussens Encephalitis :: essays research papers

The human immune governance is an amazing system that is constantly on the alert protecting us from sicknesses. Thousands of white blood cells travel in our circulatory system destroying all foreign substances that could cause harm to our body or to any of the millions of processes going on inside. Now imagine a condition where this awesome system turns against the most complex organ in the human body, the brain. Deadly as it is, this condition is cognize as Rasmussens encephalitis.The meaningful research on Rasmussens encephalitis was begun (unintentionally) by Scott Rogers and Lorise Gahring, two neurologists, who were at the time measuring the distribution of glutamate receptors in the brain. posterior on when more provocative information was put they enlisted the help of James McNamara and Ian Andrews, epilepsy experts at Duke University Medical Center.The details on Rasmussens encephalitis were very blunt at the time when the men began their research. All that was known i s that Rasmussens encephalitis was a degenerative disease of the brain that caused seizures, hemiparesis, and dementia normally in the rootage ten years of life. The seizures that were caused by Rasmussens encephalitis were unstoppable by normal anti-seizure drugs used conventionally. What the worst part of the disease was that the pathogenesis for it were not known and stock-still worse was how it developed. The first clue was delivered when Rogers and Gahring were trying to register the distribution of the glutamate receptors using antibodies, that tag on to the receptor itself. The proteins that make up the glutamate receptors(GluR) are only found inside the blood brain barrier(BBB). Glutamate and a few related amino acids are the dominant form of excitatory neurotransmitter in the central nervous system of mammals. If one of these GluRs happens to wander into the actual bloodstream, that is outside the BBB, it would be considered an outsider and destroyed immediately. So if th ese GluRs were put into the normal blood stream then the immune system would produce antibodies which could then be used in the searching for the glutamate receptors.In order to test this theory the researchers injected the GluRs into the blood stream of a normal bouncing rabbit hoping to produce good results. At this point the experiment took a dramatic turn, after receiving a few doses of the protein two of the three rabbits began to twitch, as though they were suffering the pain of an epileptic seizure.